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There were more stark differences when comparing the liver tissues between the two genotypes, where more than 400 genes were altered in ZDF livers that were not altered in the liver of lean controls
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This superiority was confirmed in a large retrospective study of 140,308 T2D patients, where tirzepatide showed significantly lower risks of all-cause mortality, MACE, and MAKE compared to GLP-1 RAs 8
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