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The large-scale randomized clinical trials targeting pharmacological agents such as niacin and cholesteryl ester transfer protein inhibitors have shown that rising endogenous HDL-C does not improve cardiovascular outcomes or all-cause mortality 100,101,102

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Additionally, specific protein 1 (Sp1) was also considered as a crucial transcription element to facilitate ACSL4 expression by binding to the promoter region of ACSL4 (Li et al

Cost-effectiveness of SGLT2is Under the assumptions of our model, use of SGLT2is was cost-effective: SGLT2i use met the AU$28,000 per QALY willingness-to-pay threshold in most one-way sensitivity and scenario analyses in both populations, and also did so in most probabilistic sensitivity analyses, especially in the secondary prevention population