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However, even between the EU member states, achieving harmonisation has often proved to be an onerous process, requiring legal referral and arbitration procedures for resolving disharmony. Tafuri and colleagues have also recently conducted a qualitative interview study concerning the assessment of cancer drugs as well as the reasons for regulatory divergence between the EMA and FDA, which he says will be published soon in Annals of Oncology

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This highlights the importance of using appropriate controls (such as counter-screens) and applying PAINS filters during drug discovery efforts to avoid being misled by artifacts

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