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Injections are more likely to cause injection-site reactions such as redness, itching, or mild swelling

Monogenic forms: Rare heterozygous coding region VKORC1 mutations cause warfarin resistance (OMIM #122700)

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Through direct oxidative damage to lipids, proteins, and DNA, ROS impair cellular function and survival in tissues prone to diabetic damage, particularly the kidneys, nerves, and retinal cells [24]

Beyond a certain threshold, higher doses don't produce additional benefits and may actually reduce effectiveness through receptor desensitization