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2015 Jan;4(1):62-6

In clinical trials, patients frequently reported feeling less puffy or bloated within the first two weeks of starting semaglutide, even before fat loss became measurable

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Eren S.H., Demirel Y., Ugurlu S., Korkmaz I., Aktas C., Gven F.M.K

However, off-label use raises several regulatory and ethical questions, particularly regarding safety, efficacy, and the FDAs role in monitoring such practices