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Agitation and aggression related pathology Studies on agitation and aggression in AD have identified various neuronal and functional changes, including atrophy, low fractional anisotropy scores, increased functional connectivity, amyloid accumulation, and hypometabolism in regions such as the amygdala, anterior cingulate, hippocampus, frontal insula, and frontal cortex (Tekin et al., 2001

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