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A key driver of this process is insulin resistance, which affects both hepatic and peripheral tissues, creating a metabolic environment that simultaneously promotes hyperglycemia and hepatic steatosis through selective pathway activation

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Pharmacological studies demonstrate that tesofensine's hypophagic (appetite-suppressing) effects are primarily mediated through indirect stimulation of 1 adrenergic receptors and dopamine D1 receptors in the hypothalamus

Co-culture of cells with G/D-CuP G/D-CuP was prepared in a confocal dish