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You may have to take very high doses to see a difference, which can lead to digestive discomfort like bloating or gas for some people

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(2022) demonstrated that salidroside from Rhodiola rosea not only reduces cerebral oxidative stress damage and inflammation induced by acute hypobaric hypoxia but also enhances energy metabolism via suppression of the nuclear factor kappa-B/nucleotide-binding oligomerization domain-like receptor protein 3 pathway