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doi: 10.3390/metabo12121251 85 AimarettiGCorneliGBaldelliRDi SommaCGascoVDuranteCet al

Another study found that the expression levels of USP1 and BCAT2 were consistently positively correlated in gene-edited mice and clinical samples

It is largely initiated by extra-mitochondrial lipid peroxidation occurring from an iron-dependent ROS accumulation, caused by abnormal iron metabolism or disturbances in the main redox systems, lipid peroxidation, and thiols, in particular GSH [30]