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GLP-1 drugs like Ozempic and Wegovy are contraindicated for patients with a family history of MTC and MEN2 (type 2a or 2b)

Candidatus Nitrosopumilus bathypathes , the dominant archaeal partner accounting for approximately 78% of the microbiome, oxidizes host-derived ammonia to gain energy for synthesizing multiple amino acids and vitamins that are incomplete or missing in the host biosynthetic repertoire, coupling detoxification with nutrient supply