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pH-dependence of production of oxidants (cu(III) and/or HO) by copper-catalyzed decomposition of hydrogen peroxide under conditions typical of natural saline waters

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Several pathways are required to maintain redox homeostasis, in particular the glutathione-glutaredoxin and thioredoxin-thioredoxin reductase systems 1

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PDK4 has been reported to block a metabolic switch from glycolysis to predominantly fatty acid synthesis and contribute to ferroptosis resistance in certain cancer cells, such as pancreatic ductal adenocarcinoma (PDAC) cells [18,19]