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Gastric bypass patients, people taking metformin long-term, and those with celiac disease or Crohn's disease may have impaired B12 absorption and genuinely benefit from injected B12 during semaglutide therapy

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Improved Metabolic and Brain Health Obesity itself is associated with: Chronic inflammation Insulin resistance Hormonal dysregulation Increased depression and anxiety risk Improving metabolic health may indirectly improve mood and cognitive function in some patients