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The FDA granted approval specifically for adults with a body mass index (BMI) of 30 or greater, or those with a BMI of 27 or greater who also have at least one weight-related condition, such as high blood pressure or type 2 diabetes

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The hypothesis that coffee consumption lowers the risk of DM2 involves several possible mechanisms as its likely effects on obesity and insulin sensitivity, which are important risk factors for DM2 [1]

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However, these lesions did not disturb the blood-brain barrier mechanism for horseradish peroxidase particles