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Clinical trial data and real-world experience suggest that the onset of appetite reduction often correlates with the medication reaching steady-state concentrations in the bloodstream, which typically occurs after approximately 4 weeks of consistent weekly dosing

doi:10.1001/jama.2023.24945 Busetto L, Bettini S, Makaronidis J, Roberts CA, Halford JCG, Batterham RL

This is one of its advantages as a stacking partner it adds metabolic benefits without introducing hormonal complexity or the need for post-cycle therapy

Similarly, the oral GLP-1 RA will also need to demonstrate their cardiovascular safety in these populations (NCT05803421)

Several main mechanisms were suggested by which obesity mediates insulin resistance, including altered secretion patterns of adipocytokines, increased levels of glucocorticoids in visceral fat tissue, and increased secretion of pro-inflammatory agents [35, 37]