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Figure 2 4.3 Nanotherapeutic and natural compound therapy for RCC Nanoparticles (NPs) are a new form of cancer treatment delivery that overcome some limitations of traditional anti-cancer drugs and can induce various cancer cells to undergo ferroptosis through various means (167, 168)

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Indeed, mutant OPG proteins expressed in co-cultured OPG-deficient osteoblasts retain their ability to bind RANKL but lack the ability to regulate RANKL transport and could not restore osteoclast formation to wild-type levels, suggesting that osteoclastogenic capacity is at least partially regulated by OPG/RANKL (Honma et al., 2013