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Five subtypes are predominant in the gastrointestinal tract: calcitonin gene-related peptide 1 (Calca), GLP-1 receptor (GLP-1R), G protein-coupled receptor 65 (Gpr65), vasoactive intestinal peptide (Vip), and oxytocin receptor (Oxtr) (24)

A low-dose regimen (e.g., 1.2 mg initially, followed by 0.6 mg after 1 h) is recommended to minimize side effects such as diarrhea