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Collectively, while ferroptosis plays a significant role in the pathogenesis of both TMJ OA and KOA, the specific effects may differ due to the distinct tissue characteristics, mechanical stress, and inflammatory environments of TMJ and knee

Warm-blooded mammals, such as rats, mice, and primates are also extremely useful subjects, but ethical issues often substantially limit the use of mammalian models

Given the notoriously limited sun exposure in the UK for much of the year, deficiency is incredibly common

In diseases characterized by chronic ER stress, such as diabetes and neurodegenerative disorders, modulating the UPR and autophagy could provide therapeutic benefits

Atherosclerosis 115 : 217224