Connective Tissue : Accelerating healing of tendons, ligaments, muscles, and bones, reducing inflammation, and aiding wound repair
(Neural Regen Res, 2022), Cushman et al
Protein misfolding and failure of clearance systems, including the autophagy-lysosome and ubiquitin-proteasome pathways, further compromise the cellular environment and lead to toxic intracellular accumulations [31, 32]
For example, KMO deficiency in male mice elevates KYNA and induces depressive-like behaviours via 7nAChR antagonism, impairing cholinergic modulation of prefrontal circuits, effects that are reversed by restoring 7nAChR signalling [71]
This ensures higher bioavailability, allowing more active glutathione to reach the bloodstream and skin cells, maximizing antioxidant and skin-brightening effects