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This study population was then divided into 3 cohorts: (1) semaglutide cohort 1470 patients who were first-time prescribed semaglutide, (2) non-GLP1-RA anti-obesity medication cohort 2784 patients who were first-time prescribed non-GLP-1RA anti-obesity medications but not semaglutide and (3) naltrexone/topiramate cohort 1430 patients who were first time prescribed naltrexone and topiramate but not semaglutide

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Subsequent and larger datasets suggest the relative risk may be smaller than this early estimate, especially when compared against agents such as empagliflozin or sitagliptin