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Patients with IBD were found to have an altered intestinal microenvironment, often correlated to higher reactive oxygen species (ROS) levels, leading to damage to the intestinal epithelial barrier and inflammatory response (4)

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One such class of transcription factor proteins is the FOXO group or forkhead family of transcription factor-O, (2) which includes four members: FOXO1, FOXO3, FOXO4, and FOXO6

Cell migration was monitored in real time using a cultured cell monitoring system (CCM-1.4XYZ/CO2, Astec Co.) and wound closure area was measured using CCM software

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