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The abi1 mutation has been shown to diminish cold-inducible gene expression, affecting the development of cold-induced freezing tolerance in abi1-knockout Arabidopsis (Leung et al., 1994

A study using an herbal extract combination comprised of 60% MO leaves ethanolic extract in doses of 100 and 250 mg/kg BW for 28 days significantly reduced BW gain, total body fat mass, the fat cell size of inguinal and epididymal white adipose tissue (WAT), liver weight, and hepatic triglycerides and increased resting energy expenditure (REE) and fat oxidation on obese rats

Acknowledgments The authors thank all the members in the JLs research group especially Qiang Chen for helpful discussions on the manuscript

Therefore, only the backbone is modelled in the final pdb file

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