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During the acute phase of AD, Th2 cytokines are markedly upregulated, facilitating immunoglobulin E (IgE) production, eosinophil infiltration, and suppression of Th1 responses, thereby amplifying Th1/Th2 imbalance (Spergel et al., 1999)

The skin reacts to this intrusion, leading to redness or discomfort

Theriogenology 79 , 299305 (2013)

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