Schematic representation of the main pathophysiological mechanisms (lipotoxicity, oxidative stress, inflammation, and gut-liver axis) and therapies under evaluation directed at these processes, including THR- agonists, FGF-21 analogs, pan-PPAR modulators, GLP-1 RAs, and GLP-1/GIP combinations, in addition to conventional treatments such as SGLT-2 inhibitors, metformin, statins, and vitamin E
Finally, the supportive sports medicine administration of L-carnitine during training in any kind of endurance sport should not go unmentioned as a conventional application
Although these conditions can be frustrating, they are often manageable through dietary changes, lifestyle modifications, and strategic supplementation
Glucagon-like peptide-1 receptor agonist liraglutide ameliorates the development of periodontitis
(2020) Evidence of a role for one-carbon metabolism in blood pressure: can B vitamin intervention address the genetic risk of hypertension owing to a common folate polymorphism