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The application should be so light that it just

Most patients see improvement by week 2 as their body adapts

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However, prior to taking such medication, a doctor should be consulted first

Bone-related diseases Bone-related diseases, such as osteoarthritis (OA) and osteoporosis (OP), are intricately associated with lipid metabolism, as abnormal lipid metabolism can exacerbate bone density loss and compromise bone quality, ultimately contributing to disease onset [252]