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To obtain orthogonal proof that our inhibitors bind to the NADP + -TGR(H) forms, we evaluated their effect on thermal stability of TGR using the thermal shift assay (TSA or differential scanning fluorometry)

Its useful in short-term therapeutic windows but less ideal for long-term use due to cost, invasiveness and the need for clinical oversight, he said

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FXR Effect on Severe Alcohol-Associated Hepatitis (FRESH) Study (FRESH)