Actively studied in Phase 2/3 trials and a major object of incretin literature
The renewed scientific interest in NAD+ stems from a convergence of discoveries in the early 2000s: the identification of sirtuins as NAD+-dependent deacylases with profound effects on aging and metabolic regulation, the demonstration that NAD+ levels decline significantly with age across multiple species, and the development of NAD+ precursors (NMN and NR) as research tools for restoring NAD+ pools
The FDA recommends using a non-oral contraceptive method or adding a barrier method for 4 weeks after starting treatment and for 4 weeks after each dose increase
Increasing the amount of glutathione in your diet isnt always viable, especially as you age or if you have a medical issue that interferes with how glutathione is produced or used
Hoffland BS, Kassavetis P, Bologna M, Teo JTH, Bhatia KP, Rothwell JC, et al