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Epigallocatechin gallate (50 mg/kg/day) also exerts multiple beneficial effects via the FGF21-AMPK pathway, including downregulation of lipogenic genes (e.g., SREBP-1c, 40%55%), reduction of hepatic lipid droplet accumulation, and enhancement of antioxidant capacity (Bakun et al., 2023

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These modifications dramatically reduce its binding to insulin-like growth factor-binding proteins (IGFBPs)

Induction of Pi form of glutathione S-transferase by carnosic acid is mediated through PI3K/Akt/NF-B pathway and protects against neurotoxicity