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However, this muscle loss isnt unique to GLP-1 RAs as weight loss in general leads to muscle mass reductions

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Kota J, Handy CR, Haidet AM, Montgomery CL, Eagle A, Rodino-Klapac LR, et al

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Liraglutide has the most robust evidence specifically in NASH, with the LEAN trial showing 39% NASH resolution compared to 9% with placebo

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Similarly, exenatide (another earlier GLP-1) showed no evidence for disease modification in a phase 3 Parkinsons disease trial

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This suggests that exercise may increase energy expenditure by activating BAT, thereby combating obesity

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