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The distribution of particles to the final map was calculated using UCSF PyEM v0.5 73

Accumulating evidence suggest that, especially in the colon, EC cells express multiple receptors for the microbiome metabolites, representing a new important link bridging the microbiome to the brain (237, 238)

Monitoring Requirements Combining these therapies requires careful lab monitoring, including: Total and free testosterone levels Estradiol (to ensure proper aromatase balance) Complete blood count (TRT can increase hematocrit) Metabolic panel (fasting glucose, HbA1c, lipids) PSA (prostate-specific antigen) Liver and kidney function Thyroid function Labs should be checked at baseline, at 6-8 weeks after initiation, and then every 3-6 months during ongoing treatment

doi:10.1002/jps.22639 Albert BB, Derraik JGB, Brennan CM, et al

Weight loss varies depending on individual metabolism and lifestyle choices