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Furthermore, the observation that the mitochondrial GPX4 isoform underwent an increased expression after treatment with RSL3 would suggest the activation of a compensatory mechanism based on GPX4 isoform switching capable of supporting and amplifying the anti-ferroptotic activity

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The problem is that hustle culture, relentless busyness, and the never-ending drive to perform and produce often lead to burnout and perpetuate feelings of exhaustion

doi: 10.1016/j.tim.2021.01.003 6 LagoumintzisGPatrinosGP

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