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In the present review, we describe the cardiovascular effects and underlying molecular mechanisms of action of GLP-1RAs in CVOTs, animal models and cultured cells, and address how these findings have transformed our understanding of the pharmacotherapy of T2DM and the prevention of CVD

Based on that study, the FDA and the European Medicines Agency approved the medication to prevent loss of kidney function, kidney failure, cardiovascular events, and death in patients with CKD, making semaglutide the first GLP-1 receptor agonist approved for this indication

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About this article Cite this article Sambath, G., Kalai, J., G., U.R