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Table 11: Results at Week 26 in a Trial Comparing TRESIBA to Insulin Glargine U -100 in Adult Patients with Type 2 Diabetes Mellitus on OAD(s)* Study G TRESIBA Administered at the Same Time Each Day or Any Time Each Day as an Add on to One and up to Three of the Following Oral Agents Metformin, Sulfonylurea or Glinides or Pioglitazone in Adult Patients The efficacy of TRESIBA was evaluated in a 26 week randomized, open label, multicenter trial in 687 patients with type 2 diabetes mellitus inadequately controlled on basal insulin alone, oral antidiabetic agents (OADs) alone or both basal insulin and OAD

Sex-dependent differences in mitochondrial resilience, calcium homeostasis and epigenetic remodelling, including differential expression of miRNAs and histone-modifying enzymes, further contribute to divergent neurotoxic outcomes [4,33]

For subsequent analysis, the authors chose a concentration of 25 mM DIM

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