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Increases SIRT-1 activity as a result of enhanced NAD+ salvage, leading to beneficial epigenetic and metabolic reprogramming, including increased oxidative phosphorylation (OXPHOS) and muscle stem cell activation 1-3

Beef liver contains 6080 micrograms of B12 per 100 grams, far exceeding beef muscle meat (23 micrograms), fish such as mackerel (1219 micrograms), eggs (0.6 micrograms each), and dairy milk (1 microgram per 200ml glass)

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Adding GIP (the tirzepatide model) deepens the effect and, somewhat counterintuitively, appears to improve gastrointestinal tolerability relative to GLP-1 alone

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