The reduction in the steatosis score was reflected in the decrease in liver TG and TC content and lipid metabolism-related gene expression
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Since the assistance of iontophoresis showed a very similar effect to the MP application alone, and iontophoresis could not be practical for routine application at home, metformin-loaded MP itself could represent a suitable option as an anti-obesity treatment ( 4.3 Polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) PVP is a polymer that has been employed for a long time in biomedical applications due to its biocompatibility, water solubility, chemical stability, and amphipathic behavior (Teodorescu and Bercea, 2015)