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Although the number of beige adipocytes did not increase, they displayed a more thermogenic phenotype characterized by smaller LDs, elevated expression of uncoupling protein 1 ( UCP1 ) and HSL , and enhanced glucose utilization, all features consistent with increased mitochondrial uncoupling and browning

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Similarly semaglutide has been shown to improve metabolic parameters in obese mice while increasing microbial diversity and enriching Akkermansia muciniphila , a mucin-degrading bacterium associated with improved gut barrier function and reduced inflammation (120)

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People deficient in B12 often experience fatigue and lack physical and mental stamina