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Short-acting GLP-1 medications (exenatide immediate-release, lixisenatide) must be administered within 60 minutes before meals for optimal post-prandial glucose control
The studies were designed to measure weight loss, not to prescribe a specific nutrition strategy
The use of Insulin Glargine, U-300 for this indication is supported by evidence from an adequate and well-controlled study in 463 pediatric patients 6 to 17 years of age with type 1 diabetes mellitus [see Clinical Studies (14.2)] and from studies in adults with diabetes mellitus [see Clinical Pharmacology (12.3), Clinical Studies (14.3)]
However, it is important to note: This effect has not been consistently demonstrated in human studies
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