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First, our investigation of the mechanism of l-carnitine action on the AMPK-ACC-CPT1 signaling pathway in synovial membranes is not sufficiently in-depth and lacks high-quality evidence

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We followed the Strengthening the Reporting of Observational studies in Epidemiology guidelines to ensure transparent and comprehensive reporting of this observational study ( 3 Results 3.1 Baseline characteristics of participants Among 142,349 participants with type 2 diabetes or obesity in the All of Us Research Program, individuals were classified into four SUD cohorts: AUD, OUD, NUD, and CUD

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