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The 2004 Valdatta double-blind RCT in Current Medical Research and Opinion enrolled 26 patients undergoing skin graft donor-site surgery, randomized to PDRN or placebo

References: Kim et al

In addition to the Leu198Leu genotype in the GPx1 gene, the Ala16Ala genotype in the manganese superoxide dismutase ( MnSOD ) gene, the most significant enzyme that protects against ROS in the human body [90], was also associated with an increased risk of breast cancer [91]

Oxidative stress: new insights on the association of non-alcoholic fatty liver disease and atherosclerosis

The Efficacy of Oral Vitamin B12 Replacement for Nutritional Vitamin B12 Deficiency