Research Use Limitation Used solely for in vitro experiments Not permitted for clinical trials involving humans Not permitted for human or veterinary administration Not permitted for investigational human use Verified and analysed with Liquilabs s.r.o
The analysis included two independently collected ventricular CSF cohorts: n=33 samples in cohort 1, which included patients who had only ventricular CSF collected (n=5, 15.2% without clinical follow-up data)
Doyle AJ, Doyle JJ, Bessling SL, Maragh S, Lindsay ME, Schepers D, Gillis E, Mortier G, Homfray T, Sauls K, Norris RA, Huso ND, Leahy D, Mohr DW, Caulfield MJ, Scott AF, Destre A, Hennekam RC, Arn PH, Curry CJ, Van Laer L, McCallion AS, Loeys BL, Dietz HC
Treatment with rapamycin reversed these impairments by downregulating the phosphorylated AKT/mTOR pathway and upregulating BNIP3, AMBRA1, and Parkin expression
We also uncover a novel function of L