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In the next 5 years, the market is expected to grow to $105 billion, representing a 17.5x increase in market value: By 2030, the US GLP-1 patient pool will include 15 million people, representing 9% of Americans with diet-related diseases

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The stress-induced KEAP1 conformational change leads to the release of the DLG motif from KEAP1, preventing NRF2 from ubiquitination by Cul3