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When the liver loses its average mass, volume, or physiological and biochemical functions due to various reasons, HGF binds to its specific receptor c-Met (cellular mesenchymal-epithelial transition) and transmits the signals into the cells, and triggers the intrinsic kinase activity of c-Met

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It is widely investigated for its interaction with nicotinamide N-methyltransferase (NNMT), an enzyme associated with metabolism and energy balance

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