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Who Should Take Semaglutide for Weight Loss The FDA approved semaglutide specifically for chronic weight management in certain patients: BMI 30 kg/m^2 (obesity) BMI 27 kg/m^2 plus at least one weight-related health issue like type 2 diabetes or hypertension Those with a history of certain medical conditions should not take semaglutide: Multiple endocrine neoplasia syndrome type 2 (MEN 2) Medullary thyroid carcinoma Severe gastrointestinal disease Always consult a healthcare professional before starting semaglutide

If B12 deficiency is suspected, well confirm it with appropriate laboratory testing

NICE NG28 similarly recommends considering periodic monitoring of B12 in people at risk on long-term metformin this is not a blanket recommendation for all metformin users, but is targeted at those with relevant risk factors or symptoms