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Thus, representative candidates that either depend directly or indirectly on NADPH provision (Figure 9A) were cloned as C-terminal ro GFP fusion, namely, KCR1 (ketoacyl-CoA reductase, involved in the elongation of fatty acids), ATR1 (NADPH:cytochrome-P450 oxidoreductase), and C4H/CYP73A5 (cinnamate 4-hydroxylase, obtained by GFP-G6PD5.4 pull-down) as indirectly NADPH-dependent cytochrome P450 enzyme ( via ATR)

Lillig CH, Berndt C, Holmgren A

Researchers discovered it while studying the biochemistry of deep sleep states

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Am J Hypertens 18 : 858863 Levine RL, Berlett BS, Moskovitz J, Mosoni L, Stadtman ER 1999 Methionine residues may protect proteins from critical oxidative damage