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In mouse models of oxygen-induced retinopathy (OIR), low-dose IL-2, which has been shown to upregulate surface TFR1 expression, was observed to expand CD4+CD25+Foxp3+ Tregs, thereby effectively attenuating retinal vasculopathy (59, 60)

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The AACE 2019 Growth Hormone Deficiency Clinical Practice Guidelines recommend maintaining IGF-1 at the 50th-75th age-adjusted percentile during GH-stimulating therapy

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