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We also identified six pathways that were downregulated with R + MSM at 4 or 8 h that were not changed at 2 h (Oxidative Stress, Immunometabolism, Cytokine Signaling, NLR Signaling, Phagocytosis, and Transcriptional Regulation)

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This degradation typically results in diminished therapeutic effect rather than the formation of harmful byproducts

This is why many people who take traditional pills feel they aren't seeing any change in their skin or energy levels