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More patients stopped taking Lillys pill due to side effects than Novos, though Lilly cautioned the study was not powered to compare the two drugs tolerability

Based on radiometric ligand-binding assays, icariin could restore the down-regulation of glucocorticoid receptor in social defeat mouse model of depression (84)

However, Hebbian-type plasticity rules introduce an intrinsic positive feedback on synaptic weight changes, making synapses prone to runaway potentiation or depression and eventual saturation, and making neuronal activity prone to runaway activation or complete silencing

Lets decode how they differ, where they meet, and how science is learning to use both for healthier aging