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These exerkines act through autocrine, paracrine, or endocrine mechanisms to mediate inter-organ communication, playing essential roles in regulating nervous system function, attenuating neuroinflammation, and promoting neural repair ( 2+ , lactate dehydrogenase (LDH), MDA, and lipid ROS, inhibited neuronal ferroptosis and lipid peroxidation, thereby ameliorating oxygen-glucose deprivation and reoxygenation (OGD/R)-induced neuronal injury

Qiu, Juanjuan, et al

However, for systemic applications tendon healing, muscle recovery, nerve support injection remains superior because it achieves higher circulating concentrations

doi: 10.1186/s12935-019-0939-2 140 LachaierELouandreCGodinCSaidakZBaertMDioufMet al

[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Hou Y., Li S., Wu M., et al