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These reactions are examples of Phase II bioconjugation reactions, most of which result in reduced toxic effects of the parent compounds or their metabolites [98,123]

doi: 10.1073/pnas.94.24.13305 137 SongsomboonC.TanprawateS.SoontornpunA.WantaneeyawongC.LouthrenooW

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Recent studies have shown that preconditioning can also activate changes at the gene level, which involves activation of molecules, such as transcription factors, transducers, sensors, and effectors, as well as numerous post-translational modifications