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10.1016/j.jmb.2011.07.019 17 ChewO.WhelanJ.MillarA

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The ratio of eumelanin to pheomelanin is genetically determined by a number of factors including the degree of base-line functional activity of the enzymes and proteins driving the mixed melanogenesis, by the melanocortin 1 receptor (MC1R) genetic polymorphism, and by the amount of the tyrosine in the melanosome [6]

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