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Nature 589 , 246250 (2021)

Notably, this reduction in systemic LPS was accompanied by a down-regulation of pro-inflammatory mediators (e.g., TLR4, NF-B, and IL-6) in the uterus, suggesting that butyrate can alleviate high-grain induced inflammation across the gut-uterus axis by fortifying the epithelial barrier 166

However, in prostate cancer treatment, particularly regarding the combined treatment of ammonium metabolism and androgens, effective studies remain scarce, with most focusing on glycolysis